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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Nat Genet. 2022 May 12;54(5):560–572. doi: 10.1038/s41588-022-01058-3

Extended Data Fig. 5. Comparison of loci identified at genome-wide significance (P < 5 x 10−8) in multi-ancestry meta-regression (180,834 cases and 1,159,055 controls), and East Asian and European ancestry-specific meta-analyses (56,268 cases and 227,155 controls, and 80,154 cases and 853,816 controls, respectively).

Extended Data Fig. 5

a, Association P-values at loci identified in East Asian and European ancestry-specific meta-analyses. Each point corresponds to a locus, plotted according to the P-value (on a −log10 scale) for the lead SNP in the multi-ancestry meta-regression on the x-axis and the lead SNP in the ancestry-specific meta-analysis on the y-axis. The TCF7L2 locus has been removed to improve clarity of presentation. Loci plotted below the y = x line show stronger evidence for association in the multi-ancestry meta-regression. b, Overlap of loci identified in multi-ancestry meta-regression and ancestry-specific meta-analyses.