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. Author manuscript; available in PMC: 2022 Nov 23.
Published in final edited form as: Nat Chem Biol. 2022 May 23;18(6):664–669. doi: 10.1038/s41589-022-01026-2

Fig. 5: Directed approach to the discovery of capnellene synthase CiTC 1.

Fig. 5:

Capnella imbricata was verified to produce capnellene-8β,10α-diol (12) and its biosynthetic precursor 11. Genome mining was applied to identify the CiTC-1 gene, and the enzyme’s activity validated in vitro to produce 11. Flask and tube art by Servier (CC-BY).