Figure 1.
Immune responses between 4-week and 12-week intervals at 28 days and 6 months post-second dose in the general cohort
Data presented are the geometric means and 95% CIs. Fold changes were calculated by dividing the immune response at 6 months post-second dose by that at 28 days post-second dose. GMRs between schedules with 4-week and 12-week intervals were adjusted for study site and paracetamol usage in the first 24 h post-vaccination (yes or no) for the 28-day data; 6-month visit time (in days) was further adjusted for the 6-month data and fold change. The vertical line is the line of no difference between 4-week and 12-week interval groups. aGMR=adjusted geometric mean ratio. ELU=ELISA units. GMR=geometric mean ratio. NT50=50% neutralisation titre. PBMCs=peripheral blood mononuclear cells. SFC=spot-forming cell. WT=wild type.