Figure 3.

Immune responses between prophylactic and reactive paracetamol use at 28 days, 3 months, and 6 months post-second dose in the 12-week interval groups

Data shown are geometric means (95% CI) in the intention-to-treat population. GMRs and two-sided 95% CIs were adjusted for study site, age, gender, and pre-boost immunogenicity (anti-spike IgG for humoral responses and ELISpot for cellular response). Numbers of participants per timepoint are shown in the appendix (p 16). aGMR=adjusted geometric mean ratio. ELU=ELISA units. FRNT₅₀=50% focal reduction neutralisation titre. GMR=geometric mean ratio. NT₅₀=50% neutralisation titre. PBMCs=peripheral blood mononuclear cells. SFC=spot-forming cell. WT=wild type.