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. 2022 May 26;15:909835. doi: 10.3389/fnmol.2022.909835

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Copyright © 2022 Oehler, Périer, Martin, Fisher, Lezmi, Kalinichev and McMahon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peripherally applied pressure to hind paws evokes calcium transients in dorsal root ganglion (DRG) neurons in vivo. (A) False color images of GCaMP6s-labeled DRG neurons in situ at baseline and after maximum mechanical stimulation (1,000 g/0.9 N). (B) Traces depict calcium transients normalize to baseline (ΔFoF) in individual neurons from mice treated with CFA and rBoNT/A1 (top), CFA and vehicle (GPB; middle), or control (PBS; bottom) upon mechanical stimulation as indicated over time.