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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: J Immunol. 2022 May 13;208(11):2461–2465. doi: 10.4049/jimmunol.2200175

Figure 2. SARS-CoV-2 T cell responses are lower in recipients of two doses of mRNA vaccines.

Figure 2.

A) IFN-γ SFU were reduced in 2X VAX group compared to other groups when their PBMCs were stimulated with USA-WA1/2020 peptide pool (left panel), similar trend was observed with Omicron peptides but without statistical significance. B) IL-2 SFU were also reduced in the 2X vax group stimulated with USA-WA1/2020 peptide pool as were C) double positive IFN-γ+IL-2+ cells. D) number of triple positive IFN-γ+IL-2+GrB+ cells was highest in 3X VAX group. Kruskal-Wallis test with Dunn’s correction for multiple comparisons. Post infection (PI) n=54, Post infection and vaccinated (PI +VAX) n=39, two dose vaccinated (2X VAX) n=210, three dose vaccinated (3X VAX) n=24. Data presented as mean ± standard error of the mean. Data from one experiment.