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. 2022 Jun 9;4(7):e542–e557. doi: 10.1016/S2589-7500(22)00091-7

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© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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COVID-19 trajectory networks

The size of the circles represent the number of individuals with that event relative to the total study population. Numbers on arrows show the proportion of individuals who transitioned to each phenotype (relative to the number of individuals in that COVID-19 wave). Numbers in square brackets show median number of days between events across all individuals with that transition. Median days between individuals who were unaffected (ie, no recorded COVID-19 phenotype) and other severity phenotypes are not shown since they were not directly comparable between waves, due to difference in length of the two periods. Thick arrows represent transitions that occurred in 0·1% of individuals or more. Thin black arrows represent transitions that occurred in 0·01% individuals or more. Any transitions that occurred in fewer than 0·01% of individuals are not shown. All included individuals were alive and had no previous COVID-19 events recorded before the start date of the specified waves.