Table 3.

Top 10 hub genes.

Hub Gene	DEMs Targeting Hub Gene
MAP2K1	miR-152-3p; miR-15a-5p; miR-34a-5p
RAF1	miR-15a-5p; miR-7-5p
IRS1	miR-15a-5p; miR-7-5p
EGFR	miR-152-3p; miR-221-3p; miR-222-3p; miR-7-5p
KIT	miR-152-3p; miR-221-3p; miR-222-3p
PIK3CB	miR-146b-5p; miR-7-5p
NRAS	miR-146b-5p; miR-152-3p
KDR	miR-15a-5p; miR-221-3p; miR-222-3p
ERBB3	miR-152-3p; miR-221-3p; miR-222-3p
PIK3R1	miR-15a-5p; miR-221-3p; miR-222-3p

MAP2K1, mitogen-activated protein kinase 1; RAF1, Raf-1 proto-oncogene, serine/threonine kinase; IRS1, insulin receptor substrate 1; EGFR, epidermal growth factor receptor; KIT, KIT proto-oncogene receptor tyrosine kinase; KDR, kinase insert domain receptor; ERBB3, Erb-B2 receptor tyrosine kinase 3; NRAS, NRAS proto-oncogene, GTPase; PIK3R1, phosphoinositide-3-kinase regulatory subunit 1; PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta.