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Treatment algorithm of AML. AML, acute myeloid leukemia; HMAs, hypomethylating agents; LDAC, low-dose cytarabine; t-AML, therapy-related AML; AML-MRC, AML with myelodysplasia-related changes; CBF-AML, core-binding factor AML. * Conceptual criteria for selecting unfit patients. 1. advanced age; 2. organ dysfunction and comorbidity(heart, lung, kidney, liver); 3. active infection; 4. congnitive impairment; 5. low performance status; 6. socio-economical issue.
