Figure 3.

Summary of future directions for FXS-iPSC research. Future studies of human iPSC-based models of FXS should aim to (A) improve reproducibility, (B) enhance the representation of neural network structure and organization through the incorporation of various glial cell types and use of assembloids, and (C) provide a comprehensive examination of neurodevelopment from early to late stages by developing models that allow for prolonged culture, such as vascularized and sliced organoid models, as well as by corroborating results through a combination of 2D and 3D models.