Table 1.
Baseline clinical, as well as biochemical characteristics of study groups.
| MEDIAN and RANGE |
Healthy Control (HC, n = 15) |
DC w/o Sepsis (n = 30) |
DC with Sepsis (n = 40) |
p Value–w/o and with Sepsis |
|---|---|---|---|---|
| Age | 32 (20–40) | 47 (22–60) | 43 (29–60) | 0.02 |
| Male: Female | 11:4 | 25:5 | 38:2 | - |
| Total Bilirubin (mg/dL) | 1 (0.3–1.5) | 6.8 (1.6–22) | 17.9 (2.2–31.7) | <0.00 |
| AST (IU/mL) | 20 (5–40) | 62 (31–510) | 118 (35–1037) | 0.04 |
| ALT (IU/mL) | 25 (10–40) | 37 (20–634) | 46 (11–233) | NS |
| INR (s) | 1 (0.8–1.2) | 1.9 (1.1–3.3) | 2.7 (1.3–6.75) | <0.00 |
| PCT (ng/mL) | 0.8 (0.2–2) | 0.4 (0.04–3.25) | 3 (0.07–88) | 0.04 |
| MELD Na | 8 (6–10) | 26 (10–37) | 34 (29–40) | <0.00 |
| Lactate (mmol/L) | 1.5 (1–2) | 1.4 (0.6–5.2) | 2.1 (0.2–13.3) | 0.02 |
| Sodium (mmol/L) | 140 (136–145) | 133 (124.3–142.7) | 129 (119–150) | NS |
| Creatinine (mg/mL) | 0.6 (0.2–1) | 0.86 (0.3–2.9) | 1.57 (0.3–4.78) | 0.03 |
| SOFA score | - | 7 (4–11) | 12 (10–16) | <0.00 |
| SIRS Criteria | ||||
| TLC (109 L) | 6 (4–11) | 6.6 (3.1–19.8) | 14 (2.7–43.6) | 0.01 |
| PULSE (/minute) | 70 (60–100) | 76 (60–110) | 94 (62–132) | 0.01 |
| RR (/minute) | 14 (12–16) | 20 (16–24) | 22 (14–34) | NS |
| TEMPERATURE | 98 (97–99) | 98.4 (97–98.9) | 98.4 (96–100) | NS |
DC (Decompensated cirrhosis), AST (aspartate aminotransferase), ALT (Alanine transaminase), INR (The international normalized ratio), PCT (procalcitonin), MELD Na (Model for End-stage Liver Disease Sodium), SOFA (Sequential organ failure assessment), SIRS (systemic inflammatory response syndrome), TLC (Total leukocyte count), RR (Respiratory rate).