Table 3.
The association between KCNQ1OT1 region methylation and the risk of breast cancer in different subgroups.
| Subgroup |
KCNQ1OT1 Region 2 |
Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) a | p | ||
| Age (year) | |||||
| <50 | <0.474 | 1.000 | <0.001 | 1.000 | <0.001 |
| ≥0.474 | 0.428 (0.265–0.687) | 0.432 (0.263–0.703) | |||
| ≥50 | <0.474 | 1.000 | 0.122 | 1.000 | 0.172 |
| ≥0.474 | 0.701 (0.447–1.099) | 0.728 (0.460–1.150) | |||
| Molecular subtype | |||||
| Luminal A | <0.474 | 1.000 | <0.001 | 1.000 | <0.001 |
| ≥0.474 | 0.449 (0.282–0.702) | 0.446 (0.276–0.706) | |||
| Luminal B | <0.474 | 1.000 | 0.085 | 1.000 | 0.107 |
| ≥0.474 | 0.696 (0.458–1.048) | 0.698 (0.450–1.080) | |||
| HER-2 | <0.474 | 1.000 | 0.061 | 1.000 | 0.042 |
| ≥0.474 | 0.484 (0.216–1.004) | 0.424 (0.176–0.936) | |||
| Basal-like | <0.474 | 1.000 | 0.315 | 1.000 | 0.420 |
| ≥0.474 | 0.653 (0.272–1.465) | 0.705 (0.289–1.614) | |||
OR, odds ratio; 95% CI, 95% confidence interval. a ORs were calculated based on the methylation levels of CpG sites increased per standard deviation and were adjusted for age, BMI, race, location, family history of other cancers, and family history of breast cancer.