Figure 6.
Effects of COX-2 deficiency on the HCD and KRASG12D/+ mediated pancreatic fibrosis and cell proliferation. (A) IHC analyses of mouse pancreata from the indicated four groups with antibodies against α-SMA and Ki67, as well as Sirius Red staining for collagen deposition. Magnification: 200×. (B,C) Quantification of α-SMA and Sirius Red stains with Fiji ImageJ software. (D) Quantification of Ki67 staining by manually counting positively stained nuclei of ductal cells. NS, not significant. ****, p-value < 0.0001.