qRT PCR analysis of inflammation-associated targets IL1b, IL10, GFAP, and LRG1. (A–D) Relative gene expression of IL1b ((A), WT old n = 7, GLA KO old n = 8), IL10 ((B), WT old n = 7, GLA KO old n = 8), GFAP ((C), WT old n = 6, GLA KO old n = 5), and LRG1 ((D), WT old n = 7, GLA KO old n = 8) in DRG of old WT (◯) and old GLA KO mice (●). Abbreviations: DRG = dorsal root ganglia; GFAP = glial fibrillary acidic protein; GLA KO = alpha-galactosidase A knockout; IL = interleukin; LRG1 = leucine-rich alpha-2-glycoprotein 1; qRT PCR = quantitative real-time polymerase chain reaction; WT = wildtype. * p < 0.05, ** p < 0.01, *** p < 0.001.