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. 2022 May 24;11(11):1730. doi: 10.3390/cells11111730

Figure 9.

Figure 9

Suppressed immune response and ion channel gene expression in murine DRG of GLA KO mice as mediators of nocifensive behavior. ① Gb3 accumulations in DRG neurons of GLA KO mice may activate PRR on immune cells. ② Clearance of Gb3 may lead to suppressed immune response represented by reduced numbers of CD206+ macrophages and reduced gene expression of IL1b, IL10, GFAP, and LRG1, counteracting exaggerated autoimmune responses. ③ Immune response mediators might influence reciprocally pain-associated ion channel gene expression via ion flux, cytokine release, and FLOT1 distribution. ④ Reduced TRPA1 and KCa3.1 expression contributes directly to thermal hyposensitivity and mechanical hypersensitivity in GLA KO mice. Abbreviations: CD = Cluster of Differentiation; DRG = dorsal root ganglia; FLOT1 = flotillin-1; Gb3 = globotriaosylceramide; GFAP = glial fibrillary acidic protein; GLA KO = alpha-galactosidase A knockout; IL = interleukin; KCa3.1 = calcium-activated potassium channel 3.1; LRG1 = leucine-rich alpha-2-glycoprotein 1; PRR = pattern recognition receptors; TRPA1 = transient receptor potential ankyrin 1. Figure 9 contains graphics from https://smart.servier.com (last access: 24 April 2022) used under the CC BY 3.0 license.