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. 2022 Jun 6;14(11):2816. doi: 10.3390/cancers14112816

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kaplan-Meier analysis of the associations of NSCLC survival with KMT2C/BCOR/KDM5C mutations and TMB level with: (A–D) patient stratified based on KMT2C/BCOR/KDM5C mutations, (E–H) patient stratified based on TMB level (12 mutations/Mb as cutoff), (I–L) patient stratified based on a combination of KMT2C/BCOR/KDM5C mutations and TMB level. Four ICB treated cohorts were analyzed, including Hellmann 2018 (A,E,I), Miao 2018 (B,F,J), Rizvi 2018 (C,G,K) and Samstein 2019 cohorts (D,H,L). PFS time was used in survival analysis except for Samstein 2019 in which only overall survival (OS) follow-up data is available.