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Therapeutic strategies of CAFs in ovarian cancer. Three aspects of strategies targeting CAFs in TME include: (a) Depletion of CAFs via specific surface markers; (b) conversion of activated CAFs to the quiescent state by inhibitors; and (c) targeting significant downstream effectors of CAFs. Image created with BioRender.com (accessed on 23 May 2022). CAFs: cancer-associated fibroblasts; TME: tumor microenvironment.
