Table 1.
Patient demographics and clinical characteristics.
| Characteristics | BALF, n (%) | Plasma, n (%) | p-Value |
|---|---|---|---|
| Number of patients | 224 | 110 | |
| Age (mean ± SD) | 67.7 ± 11.8 | 67.4 ± 10.1 | 0.82 |
| Sex | |||
| Male | 134 (59.8) | 53 (48.2) | 0.19 |
| Female | 90 (40.2) | 57 (51.8) | |
| Smoking history | |||
| Non-smoker | 106 (47.3) | 61 (55.5) | 0.38 |
| Ex-smoker | 58 (25.9) | 24 (21.8) | |
| Current smoker | 60 (26.8) | 25 (22.7) | |
| Histology | |||
| Adenocarcinoma | 187 (83.5) | 95 (86.4) | 0.52 |
| NSCLC | 37 (16.5) | 15 (13.6) | |
| Stage | |||
| III | 36 (16.1) | 11 (10) | 0.18 |
| IVA | 97 (43.3) | 48 (43.6) | |
| IVB | 91 (40.6) | 51 (46.4) | |
| Tissue EGFR mutation | |||
| Wild type | 131 (58.5) | 44 (40) | 0.12 |
| EGFR mutation | 93 (41.5) | 66 (60) | |
| Exon 19 del | 52 (55.9) | 43 (39.1) | |
| L858R | 33 (35.4) | 18 (16.4) | |
| Exon 19 del + T790M | 2 (2) | 2 (1.8) | |
| G719C + S768I | 2 (2) | 2 (1.8) | |
| L858R + G719C | 1 (1) | 1 (0.9) | |
| L858R + T790M | 1 (1) | 0 (0) | |
| G719C | 1 (1) | 0 (0) | |
| L861Q | 1 (1) | 0 (0) | |
| S768I | 0 (0) | 0 (0) | |
| T790M | 0 (0) | 0 (0) |
Abbreviations: BALF, bronchoalveolar lavage fluid; del, deletion; EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer.