Table 3.
Comparison of EGFR mutation detection rate in liquid biopsy between BALF and plasma.
| EGFR Genotype | Tissue | BALF (n = 224) | Tissue | Plasma (n = 110) | ||
|---|---|---|---|---|---|---|
| Mutant | Wild Type | Mutant | Wild Type | |||
| Mutant type | 93 | 91 | 2 | 66 | 32 | 34 |
| Wild type | 131 | 3 | 128 | 44 | 6 | 38 |
| Sensitivity | 97.8% (91/93) | (95% CI, 92.4–99.7) | 48.5% (32/66) | (95% CI, 35.9–61.1) | ||
| Specificity | 97.7% (128/131) | (95% CI, 93.5–99.5) | 86.3% (38/44) | (95% CI, 72.6–94.8) | ||
| PPV | 96.8% (91/94) | (95% CI, 90.8–98.9) | 84.2% (32/38) | (95% CI, 70.8–92.1) | ||
| NPV | 98.4% (128/130) | (95% CI, 93.5–99.5) | 52.7% (38/72) | (95% CI, 46.2–72.6) | ||
| Concordance rate | 97.7% ((91 + 128)/224) (95% CI, 94.8–99.2) | 63.6% ((32 + 38)/110) (95% CI, 53.9–72.6) | ||||
Abbreviations: BALF, bronchoalveolar lavage fluid; CI, confidence interval; EGFR, epidermal growth factor receptor; PPV, positive predictive value; NPV, negative predictive value.