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Enhancement of peak and late currents produced by endogenous voltage-gated sodium channels in rat DRG neurons by paclitaxel (PTX). Endogenous Nav1.7 currents were elicited by 40 ms depolarizing voltage steps from −80 mV to +10 mV in 5 mV increments from a holding potential of −100 mV. (a) Control data from neurons treated with DMSO. (b) Data from neurons treated with 25 nM PTX. Modified from Akin et al. [45].
