Table 1.

ReoV proteins and their known functions. This table lists all proteins encoded by the ReoV genome, the segment which encodes each protein, the known functions of the proteins, and their location in the virion.

Encoded Protein	Genome Segment	Role in Viral Life Cycle	Role in the Immune Response	Location	Reference
λ3	L1	RNA-dependent RNA polymerase	Unknown	inner capsid	[27]
λ2	L2	Capping (methyltransferase and guanylyltransferase activity) Forms interactions with β1 integrin on host cell Forms a channel for the export of viral RNA	Unknown	inner capsid	[41,51]
λ1	L3	Possible helicase/NTPase Forms the viral core	Unknown	inner capsid	[52]
μ2	M1	RNA binding NTPase RNA triphosphatase Associates with host microtubules to aid in viral factory formation	Inhibits interferon signaling	inner capsid	[24,53,54,55]
μ1 (cleaved into μ1C and μ1N)	M2	Forms pores in endosomes	Induces apoptosis	outer capsid	[56,57]
μNS + μNSC	M3	Forms viral factories Provides scaffolding for progeny core assembly	Imhibits IRF3 signaling	non-structural	[26,55]
σ1 + σ1s	S1	σ1 binds to host cell receptor such as JAM-A Glycosidase	σ1 binds host cell σ1s can induce cell cycle arrest	σ1 = outer capsid σ1s = non-structural	[55,58,59,60]
σ2	S2	Interacts with λ1 to form the viral core dsRNA binding	Unknown	inner capsid	[28,45,61]
σNS	S4	RNA binding Viral factory formation May be involved in genome packaging	Unknown	non-structrual	[31,62,63]
σ3	S3	dsRNA binding May mediate binding to NgR1	Blocks PKR Blocks RLR signaling Binds µ1 to attenuate apoptosis	outer capsid	[37,64,65]