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Signaling Pathways with Cancer Critical Genes. Hotspot panel genes in this study are shaded in red (oncogenes), and blue (tumor suppressor genes). RTK: Receptor Tyrosine Kinase; RAS: Rat Sarcoma; TGFβ: Transforming Growth Factor Beta; PI3K: Phosphoinositide 3-kinase; GPCR: G-Protein Coupled Receptor; JAK: Janus Kinase; STAT: Signal Transducer and Activator of Transcription Proteins. Figure modified from Sanchez-Vega et al. [6].
