Table 1.
List of chemical compounds used for the treatment of AD.
| Compounds | Molecular Mechanisms | References |
|---|---|---|
| Salvia officinalis | Activates PI3K/Akt | [183] |
| Curcumin | Activates PI3K/Akt/mTOR | [184] |
| Leptin | Activates PI3K/Akt | [138,139] |
| Tripchlorolide | Activates PI3K/Akt/mTOR | [188] |
| Achyranthes | Activates PI3K/Akt | [189] |
| Lithium | Activates the PI3K/Akt axis | [185] |
| Rapamycin | Inhibits mTORC1 | [186] |
| PI103 | Inhibits mTORC1 | [190] |
| AZD8055 | Inhibits mTORC1 and mTORC2 | [187] |
| INK128 | Inhibits mTORC1 and mTORC2 | [191] |
| BX912 | Inhibits PDK1 | [15] |
| OSU03012 | Inhibits PDK1 | [192] |