Table 3.
Acute and subacute toxicity.
| Type of Toxicity | Total Sample (n = 43) |
High-Dose CSI (n = 27) |
Standard-Dose CSI (n = 16) |
|||
|---|---|---|---|---|---|---|
| G1–G2 | G3 | G1–G2 | G3 | G1–G2 | G3 | |
| Radiation dermatitis | 28 (65.1%) | 1 (2.3%) | 17 (63.0%) | 1 (3.7%) | 11 (68.8%) | - |
| Pharyngeal mucositis | 22 (51.2%) | 2 (4.7%) | 15 (55.6%) | 1 (3.7%) | 7 (43.8%) | 1 (6.3%) |
| Nausea/Vomiting | 18 (41.9%) | 1 (2.3%) | 10 (37.0%) | - | 8 (50.0%) | 1 (6.3%) |
| Alopecia | 17 * (94.4%) | - | 3 (100%) | - | 14 (93.3%) | - |
| Anorexia | 16 (37.2%) | 1 (2.3%) | 8 (29.6%) | - | 8 (50.0%) | 1 (6.3%) |
| Fatigue | 15 (34.9%) | - | 8 (29.6%) | - | 7 (43.8%) | - |
| Herpes Zoster | 7 (16.3%) | - | 4 (14.8%) | 3 (18.8%) | ||
| Headache | 5 (11.6%) | 1 (2.3%) | 2 (7.4%) | 1 (3.7%) | 3 (18.8%) | - |
| Upper airway infection | 3 (7.0%) | - | 2 (7.4%) | - | 1 (6.3%) | - |
| Insomnia | 2 (4.7%) | - | 1 (3.7%) | - | 1 (6.3%) | - |
| Fever | 3 (7.0%) | - | 1 (3.7%) | - | 2 (12.5%) | - |
| Cough | 1 (2.3%) | - | - | - | 1 (6.3%) | - |
| Diarrhea | 1 (2.3%) | - | - | - | 1 (6.3%) | - |
| Myalgia | 1 (2.3%) | - | - | - | 1 (6.3%) | - |
| PRES | - | 1 (2.3%) | - | 1 (3.7%) | - | - |
| Cavernoma | 1 (2.3%) | - | 1 (3.7%) | - | - | - |
*: Percentages of alopecia are calculated considering, in total, only patients without preexisting alopecia (most patients of the high-dose CSI group, due to chemotherapy prior to PT).