Table 4.
Oncogenic role of the Sig27var25 component genes.
| Gene | Oncogenic Role in ACC | Oncogenic Role in Others | Reference |
|---|---|---|---|
| HAGHL | unknown | Unknow | NA |
| LCN12 | unknown | Unknown | NA |
| DCST2 | unknown | Unknown | NA |
| VGF | unknown | promotion of resistance to tyrosine kinase inhibitors in lung cancer | [56] |
| RGS11 | unknown | a biomarker of lung cancer | [57] |
| PRR7 | unknown | Unknown | NA |
| LINC01089 | unknown | See Table 3 | See Table 3 |
| MXD3 | unknow | promotion of medullobastoma | [58] |
| BIRC5 | Upregulation in AC and association with ACC poor prognosis [75] | promotion of cancer progression and metastasis | [59,60] |
| LTC4S | unknown | a component gene of an immune signature of breast cancer | [61] |
| FPR3 | unknown | sustain meiotic recombination checkpoint actions | [62] |
| RAB30 | unknown | association of good prognosis in triple negative breast cancer | [63] |
| RIPOR2 | unknown | association of immune cell infiltration and thus inhibition of cervical cancer | [64] |
| NOD2 | unknown | immunosuppression of tumorigenesis of gastric cancer | [69] |
| PLXNA4 | unknown | inhibition of tumor cell migration and contribution to innate immunity in working with Toll-like receptor | [65,66] |
| TFEC | unknown | regulation of lysosome biogenesis and mTOR activation | [74] |
| PI15 | unknown | biomarker of cholangiocarcinoma | [70] |
| ZFHX4 | unknown | a susceptibility locus of cutaneous basal cell carcinoma | [73] |
| LAMP3 | unknown | a hypoxia-induced gene associated with aggressive breast cancer | [71] |
| HDAC9 | unknown | increases in expression in bladder cancer | [72] |
| MCTP1 | unknown | downregulation in paclitaxel-resistant ovarian cancer cells | [67] |
| KCNN3 | unknown | suppression of bladder cancer cell migration and invasion | [68] |
| PCDHB8 | unknown | Unknown | NA |
| PCDHGB2 | unknown | Unknown | NA |
| PCDHGA5 | unknown | Unknown | NA |
NA: not available.