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Radiosensitizing effect of LY2874455 with D10 or D50 as the endpoint.
| Cell Line | D10 | D50 | ||||
|---|---|---|---|---|---|---|
| IR alone | IR + LY | Sensitization | IR alone | IR + LY | Sensitization | |
| H1703 | 8.34 | 6.93 | 20% | 4.61 | 3.52 | 31% |
| A549 | 7.24 | 5.51 | 31% | 3.47 | 2.14 | 62% |
| H1299 | 5.64 | 4.97 | 13% | 3.08 | 2.01 | 53% |
IR, X-rays; LY, LY2874455 (100 nM).
