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. 2022 Apr 14;94(22):7731–7737. doi: 10.1021/acs.analchem.1c04407

Table 1. Unexplained Sequence Alterations Introduced to the Clone 1 Anti-Lysosome RNA Aptamer7a.

node # aptamer sequence reported
1 4 GGGAAUGGAUCCACAUCUACGAAUUCAUCAGGGCUAAAGAGUGCAGAGUUACUUAGUUCACUGCAGACUUGACGAAGCUU
2A 4 biotin-24polyT-GGGAATGGATCCACATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGTTCACTGCAGACTTGACGAAGCTT
2B 20 GGGAATGGATCCACATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGTTCACTGCAGACTTGACGAAGCTT
2C 1 GGGAAUGGAUCCACAUCUACGAAUUCAUCAGGGCUAAAGAGTGCAGAGUUACUUAGUUCACUGCAGACUUGACGAAGCUU
2D 1 GGGAAUGGAUCCACAUCUACGAAUUCAUCAGGGCUAAAGAGUGCAGAGUUACUUAGUUCACUGCAGACUUGACGAAGCUU
3A 25 GGGAATGGATCCACATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGTTCACTGCAGACTTGACGAAGCTT
3B 1 HS-(CH2)6-GGGAATGGATCCACATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGGGGCGCTTCACTGCAGACTTGACGAAGCTT
3C 1 GGGAATGGATCCACCAGTGTATCTACGAATTCATCAGGGCTAAAGAGTGAAGAGTTACTTAGTTCACTGCAGACTTGACGAAGCTT
4A 1 GGGAATGGATCCACATCTACGAATTCdithiolTTTTTTATCAGGGCTAAAGAGTGCAGAGTTACTTAGTTCACTGCAGACTTGACGAAGCTT
0 2 no sequence in text or supplement
a

Unexplained insertions are bold. Unexplained substitutions are bold and underlined. Unexplained deletions are struck out, and justified or explained alterations are in light grey. The number (#) column indicates the number of publications found reporting each sequence in our analysis.