Table 1.
Top down regulated proteins differentially expressed associated with cognitive decline. A comparison of TAC-treated mice versus saline-treated mice identified 192 proteins as meeting statistical significance for differential expression
| Protein | Description | Location | Type | Fold Change (log ratio) |
|---|---|---|---|---|
| D3Z0L4 | MICOS complex subunit | Mitochondrion inner Membrane | Other | −6.79 |
| A2AER7 | Pqbpl protein | Nucleus | Other | −4.49 |
| B1AW58 | Calcium/calmodulin-dependent protein kinase ID | Nucleus | Kinase | −2.64 |
| Q9CWB7 | Glutaredoxin-like protein C5orf63 homolog | Mitochondrion | Other | −2.46 |
| Q9DBM2 | Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl- CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (eC 1.1.1.35)] | Peroxisome | Enzyme | −2.45 |
| Q9JJV5 | Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage- gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3) | Membrane | Ion channel | −2.40 |
| Q8C4C4 | Repulsive guidance molecule A | Brain | Other | −2.28 |
| Q8BKL6 | Gamma-tubulin complex component | Cytoskeleton | Other | −2.20 |
| Q62159 | Rho-related GTP-binding protein RhoC | Plasma Membrane | Other | −2.16 |
| P21952 | POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP) | Nucleus | Other | −2.14 |
| Q8VCF0 | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced- signaling adapter) (VISA) | Mitochondrion and Peroxisome | Other | −2.10 |