Figure 1.

Plasma lipid levels of Ldlr^−/− mice on the Western diet with injection of P407 or saline control. Ldlr^−/− mice were fed the Western diet and injected with P407 or saline every other day. Plasma levels of total (A) TG and (B) cholesterol were measured in mice just prior to (day 0) and during P407 or saline injection. At 7 weeks of P407 or saline injection, (C) TG and (D) cholesterol distributions of lipoprotein fractions were analyzed by SEC analysis. n = 7 mice/group. Values are mean ± SEM. Two-way ANOVA with repeated measures and assumption of inequivalence of variance followed by Šídák’s multiple pairwise comparisons test was used for statistical analysis. * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to saline controls.