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. 2022 May 30;11(11):1795. doi: 10.3390/cells11111795

Figure 3.

Figure 3

Increased lipid accumulation and CD11c levels in CD36+ monocytes of Ldlr−/− mice with P407 injection. Changes in side scatter (SSC), indicating lipid accumulation, of (A) circulating monocytes and (B) monocyte subsets defined by CD36 in Ldlr−/− mice prior to (day 0) and on days 1 and 3 of P407 or saline injection. (C) Nile red staining for lipids of circulating CD11c+ (also CD36+) monocytes in Ldlr−/− mice on day 1 of P407 or saline injection. (D) Changes in CD11c levels indicated by mean fluorescent intensity (MFI) of monocyte subsets in Ldlr−/− mice prior to (day 0) and on days 1 and 3 of P407 or saline injection. n = 5–7 mice/group. Data are shown as mean ± SEM and were analyzed by two-way ANOVA with repeated measures and assumption of inequivalence of variance, followed by Šídák’s multiple pairwise comparisons test (A,B,D) or by the unpaired Student’s t-test (C). p-values indicate comparisons of (A) monocytes or (B–D) the same monocyte subsets between the P407 group and controls.