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. 2022 May 31;14(11):2719. doi: 10.3390/cancers14112719

Table 3.

Number, incidence rates ratios (IRR), and 95% confidence intervals (95% CI) of colorectal, pancreatic, liver, trachea, bronchus and lung cancer, stomach cancer and lymphoma, corpus uteri, breast (women only), ovary, kidney, bladder, and prostate cancer by type of treatment with type 1 and type 2 diabetes (DM1; DM2). Reggio Emilia 2011-16, resident population aged 20–84 years. See Supplementary Material Table S6 for “other sites”.

Colon-Rectum (C18–C20) Pancreas (C25) Liver (C22)
Patients with DM2
in Diet-Only as Reference
Population without
DM as Reference
Patients with DM2
in Diet-Only as Reference
Population without
DM as Reference
Patients with DM2
in Diet-Only as Reference
Population without
DM as Reference
N IRR 95% CI N IRR 95% CI N IRR 95% CI N IRR 95% CI N IRR 95% CI N IRR 95% CI
Population with no DM (N = 379,103) 1279 1.00 - - 501 1.00 - - 309 1.00 - -
Population with DM (N = 21,948) 197 1.18 1.01 1.38 115 1.74 1.42 2.14 102 2.57 2.04 3.23
1. Type 1 diabetes (N = 758) 1 0.51 0.07 3.61 0 - - - 1 2.00 0.28 14.30
2. Type 2 diabetes (N = 21,190) 196 1.19 1.02 1.39 115 1.76 1.44 2.17 101 2.57 2.04 3.24
2.1 Insulin alone or in any combination (N = 2282) 20 1.32 0.64 2.74 20 1.13 0.72 1.76 17 1.72 0.70 4.21 17 2.39 1.47 3.88 21 3.28 1.46 7.37 21 5.06 3.24 7.90
2.2 Insulin alone (N = 1332) 16 1.67 0.76 3.67 16 1.45 0.88 2.38 12 2.32 0.85 6.29 12 2.70 1.52 4.79 16 4.52 1.89 10.82 16 6.18 3.72 10.27
2.3 Untreated (diet only) (N = 4077) 28 1.00 - - 28 0.86 0.59 1.25 13 1.00 - - 13 1.00 0.58 1.74 13 1.00 - - 15 1.90 1.13 3.20