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. 2022 May 31;14(11):2719. doi: 10.3390/cancers14112719

Table 7.

Number, incidence rates ratios (IRR), and 95% confidence intervals (95% CI) of neuroendocrine cancer, all sites and only from pancreas and digestive tract, by type of treatment with type 1 and type 2 diabetes (DM1; DM2), aged 20–84 years. See Supplementary Material Tables S5 and S6 for “neuroendocrine tumours in other sites” and Supplementary Table S7 site and morphology code selection [29].

Neuroendocrine Carcinoma (all) Neuroendocrine Carcinoma (only Pancreas and Digestive Tract)
Patients with DM2
in Diet-Only as Reference
Population without
DM as Reference
Patients with DM2
in Diet-Only as Reference
Population without
DM as Reference
N IRR 95% CI N IRR 95% CI N IRR 95% CI N IRR 95% CI
Population with no DM (N = 379,103) 381 1.00 - - 113 1.00 - -
Population with DM (N = 21,948) 59 1.29 0.97 1.70 11 0.95 0.31 1.79
1. Type 1 diabetes (N = 758) 0 - - - 0 - - -
2. Type 2 diabetes (N = 21,190) 59 1.37 0.99 1.73 11 0.97 0.51 1.82
2.1 Insulin alone or in any combination (N = 2282) 7 3.44 1.04 11.38 7 1.44 0.68 3.05 0 - - - 0 - - -
2.2 Insulin alone (N = 1332) 0 - - - 0 - - - 0 - - - 0 - - -
2.3 Untreated (diet only) (N = 4077) 9 1.00 - - 9 0.99 0.51 1.93 0 1.00 - - 0 - - -