Figure 1.

The number of clinical studies in cancer registered on https://clinicaltrials.gov that mention the impact of hypoxia (A), and hypoxia-inducible factor (B). We searched https://clinicaltrials.gov/ct2/home (accessed on 24 May 2022) to find all the clinical trials registered till 24 May 2022 that mention the terms “hypoxia” or “hypoxia-inducible factor”. The number of studies started each year was counted from the compiled list to draw the graphs in the figure with GraphPad Prism 9. The counts for 2022 only represent the studies started between 1 January 2022 and 24 May 2022.