Table 1.

List of mammalian peroxiredoxins and their age-associated phenotypes in mouse.

Isoenzyme.	Type	Main Subcellular Localization	Age-Associated Phenotypes in Mouse Model	Reference
PRX1	Typical 2-Cys	Cytosol	Shorter lifespan Develop age-dependent Hemolytic anemias and various cancers in PRX1 KO mice	[28]
PRX2	Typical 2-Cys	Cytosol	Aggravates aging-induced insulin resistance and declines muscle strength in PRX2 KO mice	[68]
			Aggravates age-related ovarian failure in PRX2 KO mice	[69]
PRX3	Typical 2-Cys	Mitochondria	Reduces the severity of age-related osteoarthritis in PRX3 overexpressing mice	[70]
			Reduces age-related muscle atrophy and weakness in PRX3-overexpressing mice	[71]
PRX4	Typical 2-Cys	Endoplasmic reticulum, extracellular space	PRX4 deficiency was associated with mortality in adult and aged mice	[72]
PRX5	Atypical 2-Cys	Cytosol, mitochondria, and peroxisomes	No age-associated phenotype reported yet	N.A.
PRX6	1-Cys	Cytosol, lysosomes	Decreases fertility in PRX6 KO mice	[73]