Table 2.

List of peroxiredoxin inhibitors.

Target	Inhibitor	Action	Result	Model	Reference
PRX1	Pentagamavunon-1 (PGV-1), a curcumin analog	Bound to several ROS-metabolizing enzymes, including PRX1	Induced G2/M cell cycle arrest and cell senescence	Highly metastatic breast cancer cell line, the 4T1 cells	[109]
PRX1	Epo-C12, a synthetic derivative of epolactaene	Inhibit PRX1 peroxidase but not its chaperone activity.	Exerted an apoptotic effect	BALL-1 cells	[110]
PRX1	Ferulic Acid Amides	Inhibit peroxidase activity	Improved hyperglycemia and hyperlipidemia	Streptozotocin-nicotinamide-induced diabetic rats	[111]
PRX1	Frenolicin B	Target the active cysteine residues	Increased levels of intracellular ROS to induce apoptosis and suppress tumor growth	Nude mice bearing established HCT116 or DLD-1 colorectal cancer xenografts	[108]
PRX2	Conoidin A	Inhibit peroxidase activity	Inhibited the growth of the 5-FU-resistant gastric cancer SNU620 cells	5-FU-resistant SNU620 cells	[112,113]
PRX1 /PRX2	Adenanthin, a diterpenoid isolated from the leaves of Rabdosia adenantha	Inhibit enzymes of the PRX-related chain including thioredoxin and thioredoxin reductase	Induced differentiation of acute promyelocytic leukemia (APL) expresses tumor growth in vivo and prolongs survival	Mouse APL models	[114]
			Killed these malignant liver cells in vitro and xenografts	SMMC-7721 cells were transplanted into BALB/c nude mice	[115]
			Impaired the spontaneous and antibody-dependent NK cell cytotoxicity against cancer cells	K562 and Raji cell lines, primary human NK cells	[53]
PRX1 /PRX2	Parvifoline AA	Inhibit peroxidase activity	Activated the ROS/ERK axis and the immunogenicity of hepatocellular carcinoma toward natural killer cells.	Hepa1-6 mouse allograft model	[116]
PRX6	9 amino acid peptide named as PIP-2	Inhibit of PRX6 Phospholipase A 2 Activity	Protected against Lung Injury	Mouse Model of Ventilator-Induced Lung Injury	[117]