Table 1.
Association of rs704 with AMD subtypes.
| Cases (n) | Controls (n) | OR [95% CI] | p-Value | Q-Value | |
|---|---|---|---|---|---|
| Early stage AMD | 6.657 | 17.832 | 0.978 [0.939–1.018] | 0.286 | 0.286 |
| Late-stage AMD | 16.144 | 17.832 | 1.078 [1.044–1.113] | 3.97 × 10−6 | 1.79 × 10−5 |
| Geographic atrophy (GA) | 3.235 | 17.832 | 1.048 [0.992–1.106] | 0.092 | 0.118 |
| Neovascularization (NV) | 10.749 | 17.832 | 1.09 [1.052–1.13] | 2.02 × 10−6 | 1.79 × 10−5 |
| Combined, GA & NV | 2.160 | 17.832 | 1.053 [0.987–1.124] | 0.120 | 0.135 |
| Male | 6.532 | 7.820 | 1.084 [1.034–1.139] | 1.03 × 10−3 | 2.17 × 10−3 |
| Female | 9.612 | 10.012 | 1.073 [1.027–1.119] | 1.21 × 10−3 | 2.17 × 10−3 |
Association of rs704 with AMD subtypes in the IAMDGC dataset. For all associations, the T allele indicates the effect allele. Associations were calculated in comparison with non-AMD individuals (controls). Q-values < 0.05 are indicated in bold.