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Serial viral passage experiments to select drug resistant mutants against 7d.
| Passage # | Drug selection pressure 7d (μM) |
Drug sensitivity EC50 (μM) |
Resistant mutant |
|---|---|---|---|
| P0 | 0.07 ± 0.02 | WT | |
| P1 | 0.1 | N.D. | N.D. |
| P2 | 0.1 | N.D. | N.D. |
| P3 | 0.2 | N.D. | N.D. |
| P4 | 0.4 | N.D. | N.D. |
| P5 | 0.8 | 1.9 ± 0.2 | 2C protein D183V/D323G |
N.D. = not determined.
