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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: Cell Chem Biol. 2022 May 19;29(5):730–740. doi: 10.1016/j.chembiol.2022.04.003

Figure 1. B cell evasion mechanisms.

Figure 1.

Antibody responses against immunodominant SA surface antigens are largely non-protective, whereas responses against toxins are partially protective. SpA induces B cell deletion and suppression through its super-antigenic activity, and thus creates “holes” in the B cell repertoire and primes for a skewed specific antibody response. The reason why antibodies against surface antigens are not protective is unclear.