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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: Cell Chem Biol. 2022 May 19;29(5):730–740. doi: 10.1016/j.chembiol.2022.04.003

Figure 2. T cell evasion mechanisms.

Figure 2.

Th1 / Th17 lymphocytes mediate anti-SA immunity. Staphylococcal toxins (α-toxin and LukED) induce cytolysis of mature and memory T cells. Various SA virulence determinants affect T cell priming by modulating antigen-presenting cell – naïve T cell interaction: PSM (induction of tolerogenic DC); SEB (Vβ-specific T cell activation), Peptidoglycan modification (suppression of Th17-related cytokines), Map (induction of Th2 cells), SpA (induction of Treg cells), LukED and LukAB (killing of DC). APC: Antigen Presenting Cells.