Table 2.

Data extraction and analysis process: PICO Model.

Data Extraction	Description
Reference	All identification details of the paper
Year	Year of publication
Country	Country in which the study was carried out
Study Design	Type of study conducted
Patient (P)	Population receiving both specific and nonspecific Potentially Inappropriate Prescribing (PIPs)
Intervention (I)	Any type of intervention aimed at health professionals (i.e., physicians, clinicians, pharmacists, nurses), structures (i.e., nursing homes, hospitals, pharmacies), patients, or any monitoring activities of potentially inappropriate prescriptions and costs incurred use any explicit criteria for identifying inappropriateness (such as Beers Criteria, PRISCUS list, STOPP/START criteria)
Comparator (C)	No intervention or any other intervention and no monitoring activities
Outcomes (O)	The postintervention outcome in terms of costs variation and intervention effectiveness; Avoidable costs related to inappropriate prescriptions
Cost types	The perspective of analysis (NHS, society, government, patient) and associated costs (direct healthcare costs, direct non healthcare costs, indirect costs, intangible costs)