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. 2022 May 24;23(11):5874. doi: 10.3390/ijms23115874

Figure 2.

Figure 2

Effect of SPARC on the expression of integrin subunits and the inhibition of E-cadherin (A). Representative Western blot of integrin subunits and SPARC expression in PC3 cells transduced with a lentiviral vector carrying a short hairpin RNA against SPARC (shSPARC) or a scrambled sequence (shScr) (left panel) and in LNCaP cells transduced with a lentiviral vector carrying the SPARC sequence (SPARC_HA) or a control vector (null) (right panel) (B,C). Quantification of the optic density of the Western blot shown in (A). Expression of integrin subunits and SPARC was normalized to β-actin and control cells (B,C). Data are expressed as mean ± SD (n = 3). ns = p > 0.05; * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001; Mann–Whitney U test.