Figure 2.

RBCEVs are associated with increased arterial constriction in Bcr/Abl-negative myeloproliferative neoplasms (MPNs) as RBCEVs carry MPO, which provides a prooxidant phenotype in endothelial cells, resulting in an increased arterial constriction. Reprinted with permission from [56]. Copyright 2020, American Society For Clinical Investigation.