Table 2.

The suppressive function of miR-202 in different types of digestive tract cancers.

mir-202 Function	Regulation	Samples, Cell Lines, Patient Material, Animal Model	Involved Downstream/Upstream Targets	Ref.
	(Up/Down)
Oral Cancer
suppressor	down	73 oral cancer tissue, 48 normal tissues, blood samples, cell lines	Sp1, protein kinase B	[12]
Esophageal squamous cell carcinoma (ESCC)
suppressor	down	cell lines	HSF2/Hsp70	[20]
	down	76 esophageal cancers (44 ESCC, 32 EAC) with adjacent normal tissues	n.d.	[21]
suppressor	down	30 primary ESCC tissues and adjacent noncancerous tissues, cell lines	p-FAK, p-Akt, LAMA1	[19]
Gastric Cancer
suppressor	down	60 GC tissues and adjacent normal tissues	MALAT1	[23]
suppressor	down	150 GC tissues and adjacent normal tissues, mouse xenografts	Gli1, γ-catenin, BCL-2	[22]
suppressor	down	115 GC tissues with normal tissue samples, cell lines, mouse xenografts	MALAT1, SRSF1, CCL21, mTOR	[24]
Hepatocellular carcinoma
suppressor	down	56 HCC samples, cell lines	hexokinase 2, glycolysis	[31]
suppressor	down	Eight pairs of snap-frozen HCC tumor, cell lines	LRP6	[29]
suppressor	down	Tissues from 95 patients with HCC who underwent tumor, cell lines, Tumor xenograft	NORAD, NORAD/miR-202-5p/TGF-β axis	[30]
Gall bladder cancer
pro-tumorigenic	up	Blood samples of 40 GBC patients	n.d.	[7]
Pancreatic cancer
suppressor	down	PC cell lines & orthotopic mouse xenografts	TGFβ1, EMT	[26]
suppressor	down	cell lines	hexokinase 2, inhibited glycolysis	[27]
suppressor	down	cell lines	Mxd1, SAP18	[25]
suppressor	down	28 PC cancer and adjacent normal tissue samples, cell lines, mouse xenografts	lncRNA NORAD and ANP32E	[28]
Colorectal cancer
suppressor	down	68 cases of CRC and 66 adjacent normal tissues, cell lines and xenografted nude mice	UHRF1	[33]
suppressor	down	68 CRC tissues, cell lines	1SMARCC1	[32]
suppressor	down	47 pairs of CRC tissues and adjacent normal tissues, cell lines and xenografted nude mice	NORAD	[35]
suppressor	down	98 primary CRC cancer tissues and adjacent normal tissues, cell lines, mouse xenografts	ADP-ribosylation factor-like 5A	[34]
pro-tumorigenic	up	25 CRC tumors and adjacent normal tissues, cell lines	PTEN, c-Myc AKT	[36]

n.d. = no data.