Table 4.
Reproductive system and gynecological cancers and role of miR-202.
| miR-202 Function | Regulation | Samples, Cell Lines, Patient Material, Animal Model | Involved Downstream/Upstream Molecules | Ref. |
|---|---|---|---|---|
| Cervical cancer | ||||
| suppressor | down | 105 patient samples, cell lines | PIK3CA/PI3K/Akt/mTOR pathway | [55] |
| suppressor | down | 100 CC and control tissues, cell lines | cyclin D1 | [54] |
| suppressor | down | 23 CC tissues, cell lines | MALAT1/miR-202-3p/periostin, EMT, Akt/mTOR signaling | [53] |
| Endometrial cancer | ||||
| suppressor | down | 90 tumor & 40 corresponding. normal tissues, cell lines, xenografted nude mice | FOXR2 oncogene | [59] |
| suppressor | down | 76 EC tissue samples | FGF2 and Wnt/β-catenin | [60] |
| suppressor | down | 20 EC and adjacent normal tissue samples, cell lines | NEAT1, TIMD4 | [61] |
| Uterine Leiomyosarcoma | ||||
| pro-tumorigenic | up | 39 paraffin UL tumor samples, cell lines | MYCN | [62] |
| Ovarian cancer | ||||
| pro-tumorigenic | up | 21 patient serum samples | n.d. | [6] |
| suppressor | down | 55 paired OC and para-tumor tissues, cell lines | HOXB2 | [57] |
| pro-tumorigenic | up | 23 non-epithelial ovarian germ cell tumors, 16 ovarian, 7 sex cord stromal tumors | n.d. | [58] |
| Prostate cancer | ||||
| suppressor | down | 54 PC tissues and 11 adjacent normal prostate tissues, cell lines and mouse xenografts | PIK3CA | [63] |
| inconclusive | up in high grade PC | 66 sera of patients with low- and high-grade PC | n.d. | [64] |
n.d.= no data.