Table 5.
Role of miR-202 in Osteosarcoma.
| mir-202 Function | Regulation | Samples, Cell Lines, Patient Material, Animal Model | Involved Downstream/Upstream Molecules | Ref. |
|---|---|---|---|---|
| suppressor | down | 36 tumor specimens and normal adjacent tissues, cell lines | ROCK1 | [70] |
| pro-tumorigenic | up | 8 paired tumor and normal adjacent tissues, cell lines | PDCD4 | [73] |
| suppressor | down | 16 tumor tissues and matched adjacent normal tissues, cell lines | Gli2 | [69] |
| suppressor | down | 6 metastatic OS and non-metastatic OS | CALD1, STX1A | [71] |
| suppressor | down | 32 OS without metastasis and 24 w lung metastases, 30 controls, cell lines | MALAT1 | [72] |