Table 6.
miR-202 as a tumor suppressor in other types of cancer.
| mir-202 Function | Regulation | Samples, Cell Lines, Patient Material, Animal Model | Involved Downstream/Upstream Molecules | Ref. |
|---|---|---|---|---|
| Chronic myeloid leukemia | ||||
| pro-tumorigenic | up | 30 patient samples, cells lines, xenografts of nude mice | STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis | [82] |
| suppressor | down | 15 CML samples, cell lines | HK2 | [83] |
| Follicular lymphoma | ||||
| suppressor | down | cell lines | HAS2, FAM135A | [81] |
| Glioma | ||||
| suppressor | down | 43 glioma samples and adjacent normal tissues, cell lines | MTDH, PI3K/Akt, Wnt/β-catenin pathways | [80] |
| Laryngeal cancer | ||||
| pro-tumorigenic | up | 48 laryngeal primary tumors | n.d. | [84] |
| Multiple myeloma | ||||
| pro-tumorigenic | up | cell lines | BAFF, JNK/SAPK signaling pathway | [76] |
| pro-tumorigenic | up | 40 MM patient sera, 30 healthy controls | BAFF | [5] |
| suppressor | down | cell lines | BAFF, JNK/SAPK signaling pathway | [77,79] |
| suppressor | down | 7 MM patient samples, cell lines | BAFF | [85] |
| Thyroid carcinoma | ||||
| suppressor | down | 40 PTC and adjacent normal tissues | lncRNA NORAD, EMT | [75] |
| suppressor | down | 96 pairs of PTC and adjacent normal tissue, cell lines | β-catenin, WNT signaling | [67] |
| Glioblastoma multiforme | ||||
| suppressor | down | cell lines | IR-induced K-RAS/ERK signaling, CD44 | [86] |
| Neuroblastoma | ||||
| suppressor | down | cell lines | MYCN | [87] |
| suppressor | down | cell lines | MYKN, E2F1 | [88] |
| Urinary Bladder cancer | ||||
| suppressor | down | 50 cancer and corresponding tissues, cell lines | EGFR | [89] |
n.d. = no data. PTC: papillary thyroid carcinoma.