Table 4.

Biomarkers of Myelin Biology/Demyelination.

Potential Biomarker	Study Population (n)	Sample	Results	Possible Utility
MBP	RRMS (31), CIS (18)	CSF	Correlated with EDSS scores [89]	Prognostic
	Acute exacerbation of MS (15), remission (19), slow progressive form (13)	CSF	MS patients with an acute exacerbation had higher levels than those with slower progressive MS and even higher than those in remission [90]
MOG	RRMS (2), anti-MOG (1)	CSF	Distinct myeloid cell types if subjects with neuroinflammation [93]	Diagnostic

MBP = myelin basic protein; MOG = myelin oligodendrocyte glycoprotein.