Table 3.

Area of collagen fibers in tunica media of aorta due to main drug-based protocols.

Parameter/Group	Control (n = 24)	Tac—Based Protocols (TRG, TMG) (n = 48)	CsA—Based Protocols (CRG, CMG) (n = 40)	MMF—Based Protocols (MRG, CMG, TMG) (n = 72)	Rapa—Based Protocols (TRG, CRG, MRG) (n = 64)
Area of collagen fibers in tunica media of aorta (%)
Mean ± SD	43.31 ± 19.6	88.81 ± 6.56	68.08 ± 7.0	72.3 ± 17.2	71.18 ± 14.37
Median	45.56	89.35 *	67.28 *,T	68.18 *,T	71.75 *,T
Min–Max	10.62–74.61	73.3–97.97	55.58–85.46	27.07–97.97	26.47–92.21

AM: arithmetic mean; SD—standard deviation; n—number of measured areas; Min–Max—minimum and maximum values * p < 0.05 vs. control; ^T p < 0.05 vs. Tac—based protocol.