Table 3.
Summary of active clinical trials investigating Alzheimer’s disease in relation to oxidative stress. The studies have been retrieved from clinicaltrials.gov with search keywords “Condition or disease = Alzheimer disease” and “Other terms = oxidative stress” and selecting the items with the status “Recruiting” and “Active, not recruiting”.
| ClinicalTrials.gov Identifier | Official Title | Intervention/ Treatment |
Phase | Estimated Completion Date | Ref. |
|---|---|---|---|---|---|
| NCT02800395 | Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease | Procedure: Malnutrition Screening and Perioperative Nutritional Support | Not applicable | December 2026 | [51] |
| NCT04430517 | Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer’s Dementia | Drug: Nicotinamide Riboside | Early Phase 1 | 30 April 2025 | [52] |
| NCT03514875 | Effects of Mitochondrial-targeted Antioxidant on Carotid Artery Endothelial Function and Brain Blood Flow in Mild Cognitive Impairment (MCI) Patients | Dietary Supplement: MitoQ Dietary Supplement: Placebo |
Not applicable | 1 October 2022 | [53] |
| NCT04740580 | Glutathione, Brain Metabolism and Inflammation in Alzheimer’s Disease | Dietary Supplement: Glycine Dietary Supplement: N-acetylcysteine Dietary Supplement: Alanine |
Early Phase 1 | 31 May 2025 | [54] |
| NCT03035851 | Aerobic Exercise for Older Adults at Increased Risk of Alzheimer’s Disease and Related Dementias: Harnessing Translational Physiology | Behavioral: Aerobic Exercise Behavioral: Stretch and Strength |
Not applicable | January 2025 | [55] |
| NCT02524405 | The Brain Eye Amyloid Memory (BEAM) Study: Validation of Ocular Measures as Potential Biomarkers for Early Detection of Brain Amyloid and Neurodegeneration | Other: Pittsburgh Compound B [11C]-PIB | Not applicable | December 2023 | [29] |
| NCT04213391 | Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of Sulforaphane in Patients With Prodromal to Mild Alzheimer’s Disease | Dietary Supplement: sulforaphane Dietary Supplement: Placebo |
Not applicable | 1 December 2022 | [56] |
| NCT05145881 | Evaluation of Clinical Effect of Probiotics in Alzheimer’s Disease: a Randomized, Double-blind Clinical Trial | Dietary Supplement: Low-dose Probiotics Dietary Supplement: Normal-dose Probiotics |
Not applicable | 30 June 2023 | [57] |
| NCT05007353 | The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study, Biomarker and Health Service Research Analyses | Behavioral: Structured Lifestyle Intervention Behavioral: Self-Guided Intervention |
Not applicable | 31 January 2026 | [58] |