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. 2022 May 31;11(11):1811. doi: 10.3390/cells11111811

Figure 9.

Figure 9

DFO blocked HIV-1 Tat- and gp120-induced cell death. Propidium iodide was used to measure cell death on U87MG cells after 24 h of treatment with CQ (30 µM), Tat (100 nM), and gp120 (1 nM). Cell death was significantly (p < 0.0001) increased by Tat (100 nM), gp120 (1 nM), and CQ (30 µM); 1 h pre-treatment with DFO (50 µM) blocked CQ-, Tat-, and gp120-induced cell death. A one-way ANOVA with a Tukey’s post hoc multiple comparisons test was used for analysis. Each data point represents the mean fluorescence from 20,000 cells performed independently at least five times for each group (n = 100,000). n = total number of cells for each group plotted. **** p < 0.0001.